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. 2018 Feb 12;15(4):3530–3536. doi: 10.3892/etm.2018.5858

Figure 4.

Figure 4.

Berberine improves the physical activity and physiological functions of mice with neonatal NEC. The (A) body weight and (B) food intake of mice with NEC following treatment with berberine or PBS was determined by physical activity analysis. (C) The area of infarction in the small intestine of mice with neonatal NEC was determined by staining with hematoxylin and eosin. (D) The viability of epithelial cells following treatment with berberine treatment was determined by a viability assay. (E) EGF and Bcl-2 expression in the small intestine were determined by immunohistochemistry. (F) The apoptosis of epithelial cells in the small intestine was determined by a TUNEL assay. The arrows pointed to the positive sites. **P<0.01. NEC, necrotizing enterocolitis; EGF, epithelial growth factor; Bcl, B-cell lymphoma; TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling.