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. 2018 Feb 7;15(4):3320–3328. doi: 10.3892/etm.2018.5846

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Levels of COL-X and MMP13 proteins (magnification, ×1 and ×10). (A) COL-X immunostaining. Areas enclosed by squares are enlarged in subsequent images. Black arrows indicate COL-X staining in the articular chondrocytes located in the deep and calcified zones in the central most degenerated area of articular cartilage. The red arrow indicates COL-X staining in the superficial and middle zone cartilaginous matrices. Blue arrows indicate COL-X staining in chondrocytes located in the maturation and hypertrophic zones. Green arrows indicate COL-X staining in cells located at the junction between the growth plate and metaphyseal bone. (B) MMP-13 immunostaining. Areas enclosed by squares are enlarged in subsequent images. The black arrow indicates MMP-13 staining in the superficial, middle and deep zones in the central most degenerated area of articular cartilage. The blue arrow indicates the growth plate. Green arrows indicate MMP-13 staining in the hypertrophic zone of growth plate. COL-X, type X collagen; MMP-13, matrix metollproteinase-13; PC, phosphocitrate; PC-E, PC-β ethyl ester.