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. 2018 Feb 1;15(4):4215–4220. doi: 10.3892/ol.2018.7921

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Copyright: © Xi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — (A) Effect of TcdA on apoptosis and cell cycle distribution in K562/A02 cells in the Control, TcdA (200 ng/ml) and TcdA (400 ng/ml) treatment groups. Arrows indicate apoptosis peaks. Mean cells in the G0/G1 phase increased and then decreased in the S phase following treatment with TcdA, and marked apoptosis peaks were observed. (B) TcdA induced apoptosis in K562/A02 cells. The results revealed a significant accumulation of Annexin V-fluorescein isothiocyanate positive cells and the percentage of apoptotic cells was 14.05 and 22.89%, following treatment with 200 and 400 ng/ml of TcdA, respectively. TcdA, Clostridium difficile toxin A; PI, propidium iodide.