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Leptin and oxidative stress may increase morbidity and mortality in obesity and sleep-disordered breathing. Obesity leads to dramatic increases in circulating leptin levels and leptin resistance, while IH/OSA can further augment leptin release from adipose tissue. Hyperleptinemia is associated with increased oxidative stress and can lead to increased cardiovascular risk. IH: intermittent hypoxia; OSA: obstructive sleep apnea.
