Figure 5.

PGE₂ levels in embryonic mouse tissues. Wild-type, Plaa^+/−, and Plaa^−/− embryos were sacrificed at embryonic Day 18.5 and organs were isolated and prostaglandin levels determined for the lung (A), brain (B), liver (C), and heart (D). Data represented arithmetic means ± SD from tissues representing three wild-type, three Plaa^+/−, and four Plaa^−/− embryos and obtained from three independent littermates. Significance was determined by one-way ANOVA with Tukey post hoc correction. *P < 0.05 ***P < 0.001.