Table 3.

Periventricular (1–5 mm) and deep (6–10 mm) MTR gradients in NAWM of patients with optic neuritis and healthy controls

Clinical classification at 2 years	n	MTR gradient
		Mean ± SE (pu/mm)
		Periventricular (1 to 5 mm)	Deep (6 to 10 mm)
Healthy controls	37	−0.033 ± 0.028	−0.009 ± 0.012
Optic neuritis
Did not convert to CDMS	40	0.016 ± 0.029	0.020 ± 0.010
Converted to CDMS	18	0.132 ± 0.041*	−0.010 ± 0.019
Did not convert to McDonald multiple sclerosis	18	0.015 ± 0.048	0.021 ± 0.015
Converted to McDonald multiple sclerosis	40	0.069 ± 0.028**	0.006 ± 0.011

Optic neuritis group divided according to conversion to CDMS status within 2 years. *Converters versus healthy controls P = 0.001, converters versus non-converters P = 0.020, non-converters versus healthy controls P = 0.221. Optic neuritis group also divided according to conversion to McDonald multiple sclerosis within 2 years. **Converters versus healthy controls P = 0.014; otherwise, no significant differences in gradients detected.