Table 2.
Discriminant function analysis cross-validated classification accuracy by pathological diagnosis (per cent correctly classified) using components derived from specified analyses
| Overall | CBD | PSP | PiD | TDP-A | TDP-B | TDP-C | TDP-U | aFTLD-U | AD | ALS | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Clinical CATPCA, n = 109 | 28.4 | 0 | 22.2 | 25.0 | 0 | 51.9 | 25.0 | 0 | 37.5 | 46.7 | 25.0 |
| Neuropsych testing PCA, n = 54 | 35.2 | 0 | 0 | 0 | 0 | 64.3 | 33.3 | 0 | 33.3 | 72.7 | 0 |
| GM PCA, n = 82 | 48.8 | 0 | 28.6 | 60.0 | 16.7 | 70.0 | 83.3 | 12.5 | 75.0 | 66.7 | 25.0 |
| WM PCA, n = 82 | 36.6 | 0 | 28.6 | 60.0 | 16.7 | 70.0 | 33.3 | 0 | 50.0 | 40.0 | 0 |
| Clinical + GM + WM + Neuropsych PCA, n = 75a | 57.3 | 16.7 | 40.0 | 50.0 | 20.0 | 77.8 | 66.7 | 50.0 | 75.0 | 66.7 | 50.0 |
| A priori algorithm + discriminant function analysis, n = 83 | 60.2 | 16.7 | 66.7 | 85.7 | 40.0 | 78.9 | 66.7 | 50.0 | 25.0 | 66.7 | 0 |
| A priori algorithm + discriminant function analysis + simulated amyloid/tau imaging, n = 89 | 70.8 | 25.0 | 42.9 | 85.7 | 57.1 | 94.4 | 87.5 | 50.0 | 50.0 | 100 | 0 |
AD = Alzheimer’s disease, aFTLD-U = atypical FTLD with ubiquitin positive inclusions, GM = grey matter, PiD = Pick’s disease, TDP-U = unclassifiable TDP-43, WM = white matter.
aMissing values imputed, stepwise component entry.