Figure 1.

PINK1 reduces amyloid-β accumulation in mAPP mice. (A and B) Amyloid-β (Aβ) levels in the hippocampus of the indicated transgenic (Tg) mAPP mice, 2 months post-intrahippocampal injection of AAV2-PINK1 (PINK1), AAV2-mPINK1 (mPINK1), and AAV2-GFP (GFP) were measured by ELISA. n = 9–13 mice per group. (C) Quantification of amyloid-β plaque was performed with the hippocampi of the indicated mice and (D) representative images showed amyloid-β deposits. n = 6 mice per group. (E) The bar graph presents quantification of immunoreactive bands for amyloid-β normalized to β-actin. (F) The representative immunoblots show immunoreactive bands for APP and amyloid-β proteins from indicated hippocampal homogenates, and β-actin served as a loading control. n = 3 mice per group.