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. 2017 Sep 6;140(10):2706–2721. doi: 10.1093/brain/awx221

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© The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Alpha-synuclein protein levels in L444P/+ and KO/+ mouse brains. (A) Western blotting for alpha-synuclein in the striatum. Alpha-synuclein protein levels were significantly increased in the striatum of L444P/+ mice (n = 5) compared to wild-type (+/+) control mice (n = 5). Alpha-synuclein protein levels were also increased in the striatum of KO/+ mice (n = 5) compared to wild-type control mice (n = 5), but this was not statistically significant. (C) Western blotting for alpha-synuclein in the midbrain. Alpha-synuclein protein levels were increased in the midbrain of L444P/+ mice (n = 5) compared to wild-type control mice (n = 5), but this increase did not reach statistical significance. Alpha-synuclein protein levels were increased in the midbrain of KO/+ mice (n = 5) compared to wild-type control mice (n = 5), but again without statistical significance. (C) Western blotting for alpha-synuclein in the brainstem. Alpha-synuclein protein levels were increased in the brainstem of L444P/+ mice (n = 5) compared to wild-type control mice (n = 5), but this was not statistically significant. Alpha-synuclein protein levels were also increased in the brainstem of KO/+ mice (n = 5) compared to wild-type control mice (n = 5), but this increase also did not reach statistical significance. Data were analysed with the unpaired t-test. *P < 0.05 versus control, **P ≤ 0.01 versus control, ***P ≤ 0.001 versus control.