Figure 3.

Higher DMN functional connectivity z-scores are associated with greater hippocampal grey matter volumes and higher ECN functional connectivity z-scores are associated with age-related white matter changes scores in Alzheimer’s disease patients with and without cerebrovascular disease. (A) Across AD and AD + CVD patients, higher left posterior cingulate cortex-based DMN functional connectivity z-score residuals correlated with greater hippocampal grey matter volume residuals. (B) In contrast, higher right dorsolateral prefrontal cortex-based ECN functional connectivity z-score residuals correlated with higher age-related white matter changes total score residuals. Age, gender, education, handedness and ethnicity were controlled for in all analyses. DLPFC = dorsolateral prefrontal cortex; GM = grey matter; FC = functional connectivity; PCC = posterior cingulate cortex.