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. 2017 Sep 25;140(11):3023–3038. doi: 10.1093/brain/awx232

Figure 1.

Figure 1

Pretangle tau immunoreactivity is detected in the locus coeruleus before the entorhinal cortex or hippocampus in TgF344-AD rats. Representative image (×1, inset ×40) of hyperphosphorylated tau (CP13) of 6 month (n = 5/genotype) and 16 month (n = 5/genotype) wild-type and TgF344-AD rats in the locus coeruleus (A) and mEC and hippocampus (B). Quantification of CP13+ cells in the locus coeruleus (C), mEC (D) and hippocampus (E) of wild-type (white bars) and TgF344-AD (green bars) rats. Representative images of amyloid-β accumulation (4G8; red) and Nissl (blue) in the mEC (F) and hippocampus (G) of 6-month and 16-month-old wild-type and TgF344-AD rats. Quantification of 4G8 plague burden in the mEC (striped green bars) and hippocampus (solid green bars) of TgF344-AD rats (H). *P < 0.05.