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. 2017 Sep 25;140(11):3023–3038. doi: 10.1093/brain/awx232

Figure 6.

Figure 6

DREADD-induced locus coeruleus activation restores reversal learning in TgF344-AD rats. Representative image (×10, inset ×40) of PRSx8-HA-hM3Dq DREADD (HA tag; green) expression in locus coeruleus neurons (TH+; magenta) (A). Latency to the platform during acquisition and reversal trials of the Morris water maze following vehicle (VEH) or CNO (3 mg/kg i.p.) pretreatment in wild-type (n = 7–9/treatment group) and TgF344-AD (n = 6–7/treatment group) rats (B). Swim speed during Morris water maze trials (C). Representative images (×10) of c-Fos (magenta) in the locus coeruleus (TH+; green) of DREADD-expressing rats following vehicle (VEH) or CNO (3 mg/kg i.p.) administration (D). Quantification of c-Fos+ nuclei in the locus coeruleus of DREADD-expressing wild-type (open bars) and TgF344-AD (green bars) rats following vehicle or CNO administration (E). *P < 0.05 for TgF344-AD CNO versus wild-type vehicle and TgF344-AD vehicle, ∧P < 0.05 for TgF344-AD vehicle versus wild-type vehicle.