Table 1.
Baseline characteristics of the study cohort
| Single Tx (n = 186) Median (IQR) | Repeated Tx (n = 111) Median (IQR) | P value (single vs. repeated) | |
|---|---|---|---|
| Age (years) | 62 (55–68) | 65 (57–72) | 0.004 |
| Sex (male/female; n) | 167/19 | 95/16 | 0.35 |
| Weight (kg) | 81 (72–90) | 78 (71–88) | 0.13 |
| SHFM score | 0.3 (−0.1–0.8) | 0.4 (−0.1–1.0) | 0.39 |
| NYHA class n (%) | I: 27 (15) | 11(10) | 0.04 |
| II: 84 (45) | 40 (36) | ||
| III: 69 (37) | 59 (53) | ||
| IV: 6 (3) | 1 (1) | ||
| Heart rate (b.p.m.) | 66 (60–75) | 68 (61–76) | 0.63 |
| Systolic blood pressure (mmHg) | 112 (100–130) | 112 (100–135) | 0.17 |
| Hypertension (%) | 69 | 74 | 0.43 |
| Hypercholesterolaemia (%) | 86 | 80 | 0.26 |
| Diabetes (%) | 30 | 32 | 0.61 |
| Smoking (ever; %) | 73 | 70 | 0.69 |
| Family history (%) | 53 | 54 | 0.97 |
| Creatinine (mg/dL) | 1.1 (1.0–1.4) | 1.1 (0.9–1.4) | 0.93 |
| Peripheral artery occlusive disease (%) | 12 | 16 | 0.39 |
| Coronary artery disease (1/2/3 vessel disease; %) | 23/30/47 | 23/28/49 | 0.55 |
| Previous bypass operation (%) | 38 | 42 | 0.46 |
| Time from last AMI (months) | 53 (13–122) | 72 (18–156) | 0.15 |
| Atrial fibrillation on admission (%) | 11 | 12 | 1.0 |
| ICD (%) | 24 | 23 | 1.0 |
| CRT (%) | 0.5 | 3.6 | 0.05 |
| CRT-D (%) | 5.4 | 2.7 | 0.28 |
| Mitral regurgitation (grade) | 1.0 (0.5–2.0) | 1.0 (0.5–1.5) | 0.33 |
| Quantitative LVEF (%) | 39 (29–47)a | 36 (28–44)b | 0.09 |
| Sodium (mmol/L) | 139 (137–141) | 140 (138–142) | 0.35 |
| Haemoglobin (g/dL) | 14 (13–15) | 14 (13–15) | 0.30 |
| White blood count (/nL) | 7 (6–9) | 7 (6–9) | 0.18 |
| Lymphocyte count (%) | 25 (21–27) | 25 (21–27) | 0.14 |
| Creatinine (mg/dL) | 1.1 (1.0–1.3) | 1.1 (0.9–1.4) | 0.94 |
| Uric acid (mg/dL) | 7 (6–8) | 7 (5–9) | 0.83 |
| Cholesterol (mg/dL) | 162 (136–189) | 168 (139–194) | 0.06 |
| NT-proBNP (pg/mL) | 770 (339–2522)c | 1023 (426–2299)d | 0.39 |
| Antiplatelet therapy (%) | 97 | 97 | 1.00 |
| Oral anticoagulant therapy (%) | 30 | 35 | 0.44 |
| ACEI or ATRB (%) | 95 | 96 | 0.58 |
| Beta-blocker (%) | 95 | 89 | 0.11 |
| Diuretic (%) | 83 | 87 | 0.41 |
| Statin (%) | 91 | 91 | 1.0 |
| Aldosterone blocker (%) | 43 | 48 | 0.47 |
a n = 156.
b n = 93.
c n = 183.
d n = 107.