Table 1.

Regional associations between full-length or N-truncated amyloid-β₄₂ accumulation and proteins related to amyloid-β metabolism, or accumulation of tau and apoE in Alzheimer’s disease

	Amyloid-β1-42		Amyloid-βt-42		Amyloid-βpE3-42		Amyloid-βpE11-42
	r	P-value	r	P-value	r	P-value	r	P-value
Soluble (TBS or TX) fractions
ApoE TBS	−0.49	0.106	−0.52	0.082	−0.71	0.010	−0.55	0.065
ApoE TX	−0.81	0.001	−0.33	0.302	−0.67	0.017	−0.37	0.236
APP	0.55	0.067	−0.51	0.092	−0.04	0.914	−0.36	0.251
APP-CTFβ	0.00	1.000	−0.20	0.541	−0.08	0.795	−0.19	0.565
BACE1	−0.01	0.966	0.77	0.004	0.52	0.080	0.75	0.005
PS1	0.24	0.443	−0.23	0.463	−0.04	0.897	−0.28	0.370
Neprilysin	0.00	1.000	−0.62	0.030	−0.27	0.391	−0.61	0.036
IDE	0.52	0.080	−0.37	0.240	0.02	0.948	−0.33	0.293
LRP1	0.30	0.342	−0.18	0.571	−0.13	0.697	−0.10	0.758
LDLR	−0.38	0.217	−0.46	0.134	−0.54	0.071	−0.53	0.076
GFAP	−0.62	0.031	0.12	0.712	−0.36	0.255	0.08	0.800
Synaptophysin	0.57	0.051	0.40	0.194	0.74	0.006	0.39	0.208
PSD95	0.86	<0.001	−0.20	0.541	0.36	0.245	−0.09	0.792
Insoluble (GuHCl) fraction
Tau GuHCl	0.39	0.208	0.69	0.012	0.57	0.051	0.79	0.002
ApoE GuHCl	0.11	0.729	0.97	<0.001	0.69	0.014	0.97	<0.001

Correlation coefficient (r) and P-values were acquired by the non-parametric Spearman rank test comparing the median value of normalized levels of the indicated amyloid-β species in the GuHCl fraction with the median value of normalized levels of proteins related to amyloid-β metabolism in soluble fractions (TBS or TX), or tau and apoE in insoluble (GuHCl) fraction in 19 Alzheimer’s disease cases across 12 brain regions. Significant correlations are highlighted in bold.