Table 1.
Baseline characteristics of patients with moderate aortic stenosis and stratified by left ventricular systolic dysfunction
| Characteristic | Moderate AS |
|||
|---|---|---|---|---|
| EF 36–50% (n = 687) | EF ≤ 35% (n = 403) | Overall (n = 1090) | P a | |
| Age, median (IQR) | 75 (67–82) | 75 (67–81) | 75 (67–82) | 0.411 |
| Female gender | 261 (38.0%) | 131 (32.5%) | 392 (36.0%) | 0.066 |
| History of ischaemic heart disease | 439 (63.9%) | 257 (63.8%) | 696 (63.9%) | 0.966 |
| History of hypertension | 463 (67.4%) | 254 (63.0%) | 717 (65.8%) | 0.142 |
| Diabetes | 232 (33.8%) | 160 (39.7%) | 392 (36.0%) | 0.049 |
| Peripheral vascular disease | 117 (17.0%) | 62 (15.4%) | 179 (16.4%) | 0.479 |
| Prior cerebrovascular disease | 161 (23.4%) | 82 (20.3%) | 243 (22.3%) | 0.237 |
| Renal disease | 143 (20.8%) | 72 (17.9%) | 215 (19.7%) | 0.238 |
| History of smoking | 227 (33.0%) | 131 (32.5%) | 358 (32.8%) | 0.856 |
| History of hyperlipidaemia | 330 (48.0%) | 196 (48.6%) | 526 (48.3%) | 0.848 |
| Congestive heart failure | 383 (55.7%) | 269 (66.7%) | 652 (59.8%) | <0.001 |
| Atrial fibrillation | 222 (32.3%) | 120 (29.8%) | 342 (31.4%) | 0.383 |
| Chronic obstructive pulmonary disease | 51 (7.4%) | 33 (8.2%) | 84 (7.7%) | 0.648 |
| Prior acute myocardial infarction | 253 (36.8%) | 175 (43.4%) | 428 (39.3%) | 0.031 |
| Prior percutaneous intervention | 96 (14.0%) | 48 (11.9%) | 144 (13.2%) | 0.332 |
| Prior coronary artery bypass graft surgery | 154 (22.4%) | 91 (22.6%) | 245 (22.5%) | 0.950 |
| Logistic EuroSCORE, median (IQR) | 10.0 (5.6–17.2) | 9.4 (5.0–16.6) | 9.8 (5.5–16.8) | 0.161 |
| Moderate-to-severe LVH | 257 (37.4%) | 96 (23.8%) | 353 (32.4%) | <0.001 |
| Bicuspid aortic valve | 22 (3.2%) | 6 (1.5%) | 28 (2.6%) | 0.084 |
| Aortic regurgitation (moderate–severe) | 127 (18.5%) | 49 (12.2%) | 176 (16.1%) | 0.006 |
| Mitral regurgitation (moderate–severe) | 157 (22.9%) | 137 (34.0%) | 294 (27.0%) | <0.001 |
| LVID diastole, median (IQR) | 4.9 (4.4–5.3) | 5.5 (5.0–6.1) | 5.1 (4.5–5.7) | <0.001 |
| LVID systole, median (IQR) | 3.6 (3.1–4.1) | 4.6 (3.9–5.3) | 3.9 (3.3–4.6) | <0.001 |
LVID, left ventricular internal dimension; LVH, left ventricular hypertrophy; AS is defined by mean gradient criteria.
aFor comparison of EF 36–50 vs. EF ≤ 35%.