Table 2.
Baseline characteristics of patients with severe aortic stenosis and stratified by left ventricular systolic dysfunction
| Characteristic | Severe AS |
|||
|---|---|---|---|---|
| EF 36–50% (n = 374) | EF ≤ 35% (n = 170) | Overall (n = 544) | P a | |
| Age, median (IQR) | 77 (68–83) | 74 (64–82) | 76 (67–83) | 0.032 |
| Female gender | 152 (40.6%) | 70 (41.2%) | 222 (40.8%) | 0.906 |
| History of ischaemic heart disease | 218 (58.3%) | 88 (51.8%) | 306 (56.3%) | 0.155 |
| History of hypertension | 236 (63.1%) | 95 (55.9%) | 331 (60.8%) | 0.110 |
| Diabetes | 99 (26.5%) | 46 (27.1%) | 145 (26.7%) | 0.886 |
| Peripheral vascular disease | 47 (12.6%) | 11 (6.5%) | 58 (10.7%) | 0.033 |
| Prior cerebrovascular disease | 60 (16.0%) | 23 (13.5%) | 83 (15.3%) | 0.450 |
| Renal disease | 45 (12.0%) | 28 (16.5%) | 73 (13.4%) | 0.159 |
| History of smoking | 108 (28.9%) | 43 (25.3%) | 151 (27.8%) | 0.387 |
| History of hyperlipidaemia | 151 (40.4%) | 62 (36.5%) | 213 (39.2%) | 0.387 |
| Congestive heart failure | 213 (57.0%) | 114 (67.1%) | 327 (60.1%) | 0.026 |
| Atrial fibrillation | 109 (29.1%) | 55 (32.4%) | 164 (30.1%) | 0.450 |
| Chronic obstructive pulmonary disease | 23 (6.1%) | 7 (4.1%) | 30 (5.5%) | 0.336 |
| Prior acute myocardial infarction | 119 (31.8%) | 42 (24.7%) | 161 (29.6%) | 0.092 |
| Prior percutaneous intervention | 28 (7.5%) | 8 (4.7%) | 36 (6.6%) | 0.227 |
| Prior coronary artery bypass graft surgery | 63 (16.8%) | 17 (10.0%) | 80 (14.7%) | 0.037 |
| Logistic EuroSCORE, median (IQR) | 9.9 (5.8–16.9) | 9.3 (4.8–18.1) | 9.7 (5.5–17.3) | 0.294 |
| Moderate-to-severe LVH | 200 (53.5%) | 61 (35.9%) | 261 (48.0%) | <0.001 |
| Bicuspid aortic valve | 10 (2.7%) | 7 (4.1%) | 17 (3.1%) | 0.370 |
| Aortic regurgitation (moderate–severe) | 80 (21.4%) | 44 (25.9%) | 124 (22.8%) | 0.247 |
| Mitral regurgitation (moderate–severe) | 65 (17.4%) | 67 (39.4%) | 132 (24.3%) | <0.001 |
| LVID diastole, median (IQR)a | 4.8 (4.2–5.3) | 5.3 (4.8–5.9) | 4.9 (4.4–5.5) | <0.001 |
| LVID systole, median (IQR)a | 3.6 (3.0–4.0) | 4.4 (3.8–5.0) | 3.8 (3.2–4.4) | <0.001 |
LVID, left ventricular internal dimension; LVH, left ventricular hypertrophy; AS is defined by mean gradient criteria.
aFor comparison of EF 36–50 vs. EF ≤ 35%.