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. 2018 Feb 20;4:31. doi: 10.1038/s41420-017-0023-4

Fig. 4. TSP-1 restores the Aβ-induced decrease of p-Drp1 to Drp1 ratio.

Fig. 4

a In HT22 cells, mitochondrial fission/fusion-related protein levels were determined by WB under Aβ- and/or TSP-1-treated condition. b–e Phospho-Drp1 (Ser637) to Drp1 ratio, which is important for mitochondrial dynamics was recovered by TSP-1 against Aβ toxicity while other fusion/fission proteins such as Mfn1, OPA1, and Fis1 were not changed. Data are presented as mean ± SEM. *p < 0.05, ***p < 0.001 vs. Aβ-treated cells; n.s. means statistically nonsignificant. Data were obtained from at least five replicates