Fig. 5. α2δ1 receptor is important to mediate the regulating effect of TSP-1 for the ratio of pDrp-1 to Drp1.

a, b Gabapentin (100 μM), a blocker for TSP-1-α2δ1 interaction, suppressed the ability of TSP-1 to maintain p-Drp1 levels. Data are presented as mean ± SEM. ***p < 0.001 vs. Veh (DMSO)-treated cells; ^##p < 0.01 vs. Aβ-treated cells; ^&&&p < 0.001 vs. GBP + TSP-1-treated cells; n.s. means statistically nonsignificant. Data were obtained from at least five replicates