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. 2018 Feb 20;4:30. doi: 10.1038/s41420-018-0034-9

Fig. 5. Cytochrome c and caspase-12 independently induce caspase-9 activation in M. fortuitum infected HKM.

Fig. 5

HKM pre-treated with or without indicated inhibitors were infected with M. fortuitum and caspase-9 activity measured 24 h p.i. Vertical bars represent mean ± SE (n = 3).*P < 0.05, compared to HKM; #P < 0.05, compared to HKM + MF. HKM, control headkidney macrophage; HKM + MF, HKM infected with M. fortuitum; HKM + Z-LEHD-FMK + MF, HKM + Z-ATAD-FMK + MF, HKM + RR + MF, HKM + CsA + MF, HKM pre-treated with Z-LEHD-FMK, ZATAD-FMK, RR, CsA respectively and infected with M. fortuitum