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. 2018 Mar 7;8:4108. doi: 10.1038/s41598-018-22339-0

Figure 1.

Figure 1

PA induces lipid accumulation in hepatocytes. (a–c) L02 hepatic cells exposed to different concentrations (200 μM, 400 μM) of PA for different time (12 h, 24 h). Lipid droplets accumulation and TG levels were determined by Oil Red O staining (400X) and TG assay respectively (*P < 0.05, **P < 0.01). (d) L02 cells exposed to different concentrations (100–500 μM) of PA for different time (12 h, 24 h). CCK-8 assay was used to detect cell viability (*P < 0.05, **P < 0.01). (e) L02 cells were treated with celecoxib at different concentrations (5–40 μM) for 24 h. CCK-8 assay was used to detect cell viability (*P < 0.05, **P < 0.01).