Fig. 3. Therapeutic effects of transplanted 327-sensitized, 534-sensitized, and 755-sensitized CTLs in mice bearing HT-29 xenografts.

a The schema HT-29 cell inoculation and injection of PBMCs. b Groups treated with peptide-sensitized CTLs showed a greater decrease in tumor volume than the control group treated with non-peptide-stimulated T cells. Points, mean (n = 7); bars, standard deviation (SD). c At the end of the experiment, tumors were removed, and images were taken with a digital camera. Tumor volume (d) and tumor weights (e) of the killed mice were evaluated 29 days after tumor implantation. f Effect of CTLs on mouse body weights. g Images from immunohistochemistry of CD8+ staining indicated that CD8+ CTLs successfully infiltrated into tumor tissues of the experimental groups