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. 2018 Mar 7;9(3):372. doi: 10.1038/s41419-018-0382-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Using two programs (starbase and microRNA.org), we found that both HCP5 and ST6GAL2 are potential targets of miR-22-3p, miR-186-5p and miR-216a-5p. b, c A dual luciferase reporter assay was used to test whether HCP5 and ST6GAL2 are targets of miR-22-3p, miR-186-5p and miR-216a-5p. d Western blot analysis showed that the knockdown of miR-22-3p, miR-186-5p, or miR-216a-5p in FTC133 cells triggered a significant increase in ST6GAL2 protein expression. e, f An RIP experiment showed that HCP5 was enriched in Ago2-contaning miRNAs compared with IgG; miR-22-3p, miR-186-5p and miR-216a-5p were also detected in the same precipitate (*pvalue < 0.05)