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. 2018 Mar 7;8:4161. doi: 10.1038/s41598-018-22277-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of AD-specific atrophy similarity measure at the individual-level. The AD-specific atrophy similarity scores differed between Case #96 - CN (left, 3.7) and Case #1256 - AD (right, 91.6). The standardized value (Z-score) maps were computed to visualize the AD-specific atrophy similarity. Positive Z-scores (red) indicate that the regions of brain are similar to the AD-specific patterns of atrophy. AD = Alzheimer’s disease; CN = cognitively normal; MMSE = mini-mental state examination.