Fig. 3. Effects of FGF2 injection with or without BMT on histologic parameters and intestinal inflammation.

a Representative hematoxylin and eosin-stained sections of mouse small intestine at day 5 post-irradiation. Magnification ×40 (first row, scale bar 500 μm), ×200 (second row, scale bar 100 μm), and ×400 (third row, scale bar 50 μm). b Quantification of crypt counts per circumference, villi height, and basal lamina length. n = 5 in each group. c Intestinal IL-1α and IL-6 levels were measured in tissue lysates obtained at day 3 post-irradiation. Values are means ± SEM; n = 4 in each group. d In vivo intestinal permeability was determined by FITC–dextran serum concentration at 4 h after oral gavage; day 3 post-irradiation, n = 3 in each group. e Cldn15, Epcam, and Vil1 expression levels at day 3 post-irradiation; n = 4 in each group. Values are mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001