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. 2018 Mar 7;8:4111. doi: 10.1038/s41598-018-22484-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Suppression of GADD45A increased cisplatin-induced cell apoptosis. (A) Annexin V/PI staining flow cytometry was performed to detect apoptosis. The lower right quadrant of the fluorescence activated cell sorting (FACS) indicates the percentage of early apoptotic cells (Annexin V-stained cells), while the upper right quadrant indicates the percentage of late apoptotic cells (Annexin V+/PI-stained cells). The cell distribution was analyzed using flow cytometry after cisplatin treatment (4 μM, 24 h). The images are representative of three independent experiments. (B) Histogram showing the percentage of early and late apoptotic A375 cells after treatment with 4 μM cisplatin for 24 h. Student’ s t-test, *p < 0.05, **p < 0.01, ***p < 0.001.