Table 1.
Summary of the relative-fold change of genes by RT² Profiler™ PCR Array. Genes with significant (p < 0.05) upregulation or downregulation >2-fold were selected after 48 hours of cisplatin treatment (4 μM).
| Gene Symbol | Fold upregulation | p-value | Gene function |
|---|---|---|---|
| BTG2 | 22.8 | 0.0001 | Other genes involved in DNA repair |
| ERCC1 | 3.1 | 0.0045 | Nucleotide excision repair |
| GADD45A | 5.5 | 0.0292 | DNA repair, Cell cycle arrest |
| GADD45G | 6.4 | 0.0169 | Apoptosis |
| PPP1R15A | 4.5 | 0.0451 | Apoptosis |
| SEMA4A | 2.1 | 0.0213 | Damaged DNA Binding |
| XPC | 3.1 | 0.0215 | Nucleotide excision repair |
| BRCA1 | −10.2 | 0.0217 | Damaged DNA Binding, Apoptosis |
| DMC1 | −3.7 | 0.0205 | Damaged DNA Binding |
| FEN1 | −2.9 | 0.008793 | Double-strand Break Repair |
| XRCC6 | −3.2 | 0.0104 | Double-strand Break Repair |
| GTSE1 | −24.5 | 0.0274 | Cell Cycle Arrest |
| RAD51 | −5.2 | 0.0056 | Damaged DNA Binding |
| RPA1 | −2.9 | 0.0079 | Other genes involved in DNA repair |
| XRCC2 | −9.6 | 0.0086 | Damaged DNA Binding |
Data from three independent experiments. Statistical analysis was performed using One-Way ANOVA with Bonferroni’s post-hoc test.