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. 2018 Mar 7;8:4124. doi: 10.1038/s41598-018-22284-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map of PSI values for alternative ES events in the Tnip1 KO mouse model dataset and the human psoriasis dataset. Yellow: high PSI. Blue: low PSI. (a) The heat map of the PSI values between three KO samples and three wild-type samples in mice. 64 of 181 ES events have more inclusion of variable exons in psoriasis, and 117 ES events have less inclusion of variable exons in psoriasis. (b) Heat map of the PSI values between 92 lesional psoriatic skins and 82 normal control skins in humans. 98 of 217 ES events have more inclusion of variable exons in psoriasis, and 119 ES events have less inclusion of variable exons in psoriasis.