Table 1.

Identification of the conserved splicing events between the Tnip1 KO mouse model dataset and the human psoriasis dataset.

Gene in human	Gene in mouse	ΔΨ in human	ΔΨ in mouse	Isoform conservation	PSI consistency
ABI1	Abi1	‒0.133	‒0.095	both	Y
ARHGAP12	Arhgap12	‒0.069	‒0.309	both	Y
ATP5C1	Atp5c1	0.104	0.259	both	Y
CTTN	Cttn	‒0.054	‒0.159	both	Y
DNM1L	Dnm1l	‒0.096	‒0.221	both	Y
EXOC1	Exoc1	0.186	0.198	both	Y
FBLN2	Fbln2	‒0.172	‒0.173	both	Y
FNBP1	Fnbp1	‒0.137	‒0.269	both	Y
GOLGA2	Golga2	‒0.099	‒0.144	both	Y
GOLGA4	Golga4	0.058	0.086	both	Y
MYH11	Myh11	‒0.064	‒0.225	both	Y
MYL6	Myl6	‒0.101	‒0.294	both	Y
MYO1B	Myo1b	‒0.109	‒0.206	both	Y
PAM	Pam	‒0.096	‒0.327	both	Y
SEC31A	Sec31a	‒0.105	‒0.115	both	Y
SLK	Slk	0.107	0.217	both	Y
SPAG9	Spag9	‒0.100	‒0.226	both	Y
ZMYND11	Zmynd11	0.061	0.365	both	Y
AXL	Axl	‒0.060	0.091	both	N
DMKN	Dmkn	‒0.180	‒0.078	hs_inc = mm_excla	N
MLX	Mlx	0.089	‒0.132	both	N
MPRIP	Mprip	‒0.127	0.187	both	N
NDRG2	Ndrg2	0.126	‒0.159	both	N
POSTN	Postn	‒0.072	‒0.195	hs_inc = mm_exclb	N

The column “PSI consistency” marks ‘Y’ for the 18 splicing events conserved in both mice and humans.

^aThe ΔΨ s are of the same negative signs, meaning psoriatic samples have more exclusion for the splicing events in DMKN/Dmkn of both species. However, the isoform with more inclusion of the variable exon in the human (hs_inc) is conserved with the isoform with more exclusion of variable exon in the mouse (mm_excl). Therefore, the event is not conserved.

^bThe ΔΨ s are of the same negative signs, meaning psoriatic samples have more exclusion for the splicing events in POSTN/Postn of both species. However, the isoform with more inclusion of the variable exon in the human (hs_inc) is conserved with the isoform with more exclusion of variable exon in the mouse (mm_excl). Therefore, the event is not conserved.