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. 2018 Feb 14;4:24. doi: 10.1038/s41420-018-0032-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Lewis lung carcinoma (LL/2) cells were injected subcutaneously into female C57BL/6 mice and inoculated for 10 days. These mice, with LL/2-bearing tumors, were then intraperitoneally (i.p.) administered with 100, 50, or 25 mg/kg #2714; vehicle was used as a control. Tumor volumes were measured every other day for 14 days starting from the initiation of treatment. b Growth inhibition rates were measured by weighing the tumors of experimental animals killed at the end of the experiment after #2714 was administered to LL/2-bearing mice xenograft models. c The average body weight changes of each group were measured every other day. d A significant increase in survival in #2714-treated mice was observed. e An immunohistochemical analysis was conducted to detect the effects of #2714 on tumor angiogenesis inhibition and apoptosis induction by detecting CD31 and CD105 after animals were administered #2714 for 14 days. A TUNEL assay was used to detect the LL/2-bearing tumor mice xenograft sections. The representative fields of tumor sections from the TUNEL assay were observed under an inverted fluorescence microscope with a camera (log-rank, mean ± SEM, n = 10, 200×; *p < 0.05, **p < 0.01)