Figure 6. LY2801653 inhibits growth of orthotopic tumor xenografts in SCID mice.

A. Quantitative analysis of bioluminescence photon counts as a measure of A549-luc-C8 cell line tumor growth in SCID. Oral gavage treatment with LY2801653 at 20 mg/kg/day reduced A549-luc-C8 tumor growth significantly relative to vehicle control (p<0.05). B. Representative images of the whole body. C. Representative fluorescence images of whole body with open chest and lung. D. H&E histologic staining to evaluate presence or absence of tumor in chest cavity. Error bars represent SEM. P-value between mean radiance of vehicle control and LY2801653 by two-tailed Student’s t test (*: p-value <0.05).