Table 1. The Key Transcription Factors of H1993 treatment with LY2801653 (3 nM).
Metacore™ (GeneGo) analysis based on identified PamGene 12 siginificant genes (Fig. 3B) which are modulated by LY2801653 treatment (3 nM). Note: ‘Total Nodes’ indicate the total number of genes analyzed whereas ‘Seed Nodes’ indicate the number of genes out of the Total Nodes that were involved with that particular transcription factor.
| No | Gene | GO processes | Total Nodes | Seed Nodes | p-Value |
|---|---|---|---|---|---|
| 1 | STAT3 | enzyme linked receptor protein signaling pathway (75.0%), cell surface receptor linked signaling pathway (100.0%), transmembrane receptor protein tyrosine kinase signaling pathway (66.7%), protein phosphorylation (66.7%), signal transduction (100.0%) | 12 | 11 | 2.15E-43 |
| 2 | SP1 | enzyme linked receptor protein signaling pathway (66.7%), cell surface receptor linked signaling pathway (91.7%), transmembrane receptor protein tyrosine kinase signaling pathway (58.3%), protein phosphorylation (58.3%), signal transduction (91.7%) | 12 | 11 | 2.15E-43 |
| 3 | p53 | enzyme linked receptor protein signaling pathway (72.7%), cell surface receptor linked signaling pathway (100.0%), protein phosphorylation (63.6%), signal transduction (100.0%), transmembrane receptor protein tyrosine kinase signaling pathway (54.5%) | 11 | 10 | 5.75E-39 |
| 4 | c-Myc | cell surface receptor linked signaling pathway (100.0%), enzyme linked receptor protein signaling pathway (66.7%), protein phosphorylation (66.7%), interspecies interaction between organisms (55.6%), positive regulation of transport (55.6%) | 9 | 8 | 1.33E-30 |
| 5 | c-Jun | cell surface receptor linked signaling pathway (100.0%), enzyme linked receptor protein signaling pathway (66.7%), interspecies interaction between organisms (55.6%), signal transduction (100.0%), signaling (100.0%) | 9 | 8 | 1.33E-30 |
| 6 | STAT1 | cell surface receptor linked signaling pathway (100.0%), enzyme linked receptor protein signaling pathway (66.7%), positive regulation of transport (55.6%), signal transduction (100.0%), transmembrane receptor protein tyrosine kinase signaling pathway (55.6%) | 9 | 8 | 1.33E-30 |