Table 1. The Key Transcription Factors of H1993 treatment with LY2801653 (3 nM).
Metacore™ (GeneGo) analysis based on identified PamGene 12 siginificant genes (Fig. 3B) which are modulated by LY2801653 treatment (3 nM). Note: ‘Total Nodes’ indicate the total number of genes analyzed whereas ‘Seed Nodes’ indicate the number of genes out of the Total Nodes that were involved with that particular transcription factor.
No | Gene | GO processes | Total Nodes | Seed Nodes | p-Value |
---|---|---|---|---|---|
1 | STAT3 | enzyme linked receptor protein signaling pathway (75.0%), cell surface receptor linked signaling pathway (100.0%), transmembrane receptor protein tyrosine kinase signaling pathway (66.7%), protein phosphorylation (66.7%), signal transduction (100.0%) | 12 | 11 | 2.15E-43 |
2 | SP1 | enzyme linked receptor protein signaling pathway (66.7%), cell surface receptor linked signaling pathway (91.7%), transmembrane receptor protein tyrosine kinase signaling pathway (58.3%), protein phosphorylation (58.3%), signal transduction (91.7%) | 12 | 11 | 2.15E-43 |
3 | p53 | enzyme linked receptor protein signaling pathway (72.7%), cell surface receptor linked signaling pathway (100.0%), protein phosphorylation (63.6%), signal transduction (100.0%), transmembrane receptor protein tyrosine kinase signaling pathway (54.5%) | 11 | 10 | 5.75E-39 |
4 | c-Myc | cell surface receptor linked signaling pathway (100.0%), enzyme linked receptor protein signaling pathway (66.7%), protein phosphorylation (66.7%), interspecies interaction between organisms (55.6%), positive regulation of transport (55.6%) | 9 | 8 | 1.33E-30 |
5 | c-Jun | cell surface receptor linked signaling pathway (100.0%), enzyme linked receptor protein signaling pathway (66.7%), interspecies interaction between organisms (55.6%), signal transduction (100.0%), signaling (100.0%) | 9 | 8 | 1.33E-30 |
6 | STAT1 | cell surface receptor linked signaling pathway (100.0%), enzyme linked receptor protein signaling pathway (66.7%), positive regulation of transport (55.6%), signal transduction (100.0%), transmembrane receptor protein tyrosine kinase signaling pathway (55.6%) | 9 | 8 | 1.33E-30 |