Table 1.
Conditional false discovery rate: birth weight loci given type 2 diabetes (birth weight|T2D)
| SNP | SNP chromosome | SNP position | Birth weight P-value | cFDR (birth weight|T2D) | Nearby gene |
|---|---|---|---|---|---|
| rs1012635 | 6 | 20783274 | 4.10 × 10−3 | 1.91 × 10−2 | CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) |
| rs1042725 | 12 | 64644614 | 2.80 × 10−9 | 2.21 × 10−7 | High mobility group AT-hook 2 (HMGA2) |
| rs10882028 | 10 | 93933880 | 2.90 × 10−6 | 1.07 × 10−4 | Cytoplasmic polyadenylation element binding protein 3 (CPEB3) |
| rs12610185 | 19 | 19582722 | 7.70 × 10−3 | 4.62 × 10−2 | PBX homeobox 4 (PBX4) |
| rs231354 | 11 | 2662927 | 2.30 × 10−3 | 2.45 × 10−2 | Potassium voltage-gated channel subfamily Q member 1 (KCNQ1) |
| rs2782980 | 10 | 115771517 | 6.40 × 10−5 | 8.30 × 10−3 | Adrenoceptor beta 1 (ADRB1) |
| rs4677887 | 3 | 124582913 | 3.60 × 10−4 | 1.67 × 10−2 | Adenylate cyclase 5 (ADCY5) |
| rs4753073 | 11 | 92357123 | 2.70 × 10−3 | 2.23 × 10−2 | Melatonin receptor 1B (MTNR1B)||solute carrier family 36 member 4 (SLC36A4) |
| rs916419 | 22 | 48555425 | 3.50 × 10−4 | 4.05 × 10−2 | Bromodomain containing 1 (BRD1) |
| rs871961 | 3 | 150061208 | 6.70 × 10−5 | 4.26 × 10−2 | Carboxypeptidase B1 (CPB1)||carboxypeptidase A3 (CPA3) |
| rs1258191 | 10 | 50663125 | 1.20 × 10−5 | 2.71 × 10−2 | Mitogen-activated protein kinase 6 pseudogene 6 (MAPK6PS6)|| LOC727726 |
| rs6016373 | 20 | 38587509 | 1.60 × 10−5 | 4.06 × 10−2 | Heat shock protein family E (Hsp10) member 1 pseudogene 1 (HSPE1P1)||MAF bZIP transcription factor B (MAFB) |
| rs222857 | 17 | 7105287 | 1.70 × 10−5 | 4.02 × 10−2 | Claudin 7 (CLDN7) |
*
The chromosome position in the GRCh37.p5 sequence of Genome Build 37.3 (ftp://ftp.ncbi.nlm.nih.gov/genomes/Homo_sapiens/ARCHIVE/BUILD.37.3, accessed 1 May 2015).
SNP, single nucleotide polymorphism; cFDR, conditional false discovery rate.