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. Author manuscript; available in PMC: 2018 Mar 7.
Published in final edited form as: J Diabetes. 2017 Jan 20;9(10):898–907. doi: 10.1111/1753-0407.12510

Table 3.

Top five most significant gene ontology terms enriched for genes associated with pleiotropic SNPs

GO ID GO terms log (OR) P-value
GO:0001973 Adenosine receptor signaling pathway 9.66 4.29 × 10−6
GO:0035588 G-Protein-coupled purinergic receptor signaling pathway 9.66 4.29 × 10−6
GO:0007195 Adenylate cyclase-inhibiting dopamine receptor signaling pathway 9.14 9.79 × 10−6
GO:0035587 Purinergic receptor signaling pathway 8.66 2.43 × 10−5
GO:0007191 Adenylate cyclase-activating dopamine receptor signaling pathway 8.47 3.42 × 10−5

Gene ontology (GO) enrichment analysis was performed using the GOEAST program (http://omicslab.genetics.ac.cn/GOEAST/, accessed 10 May 2016), which gave “P > 0” when the obtained P-value was less than the minimum float value (1.17549435082229 × 10−38). OR, odds ratio.