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. Author manuscript; available in PMC: 2018 Mar 7.
Published in final edited form as: Neuropharmacology. 2017 Nov 6;129:26–35. doi: 10.1016/j.neuropharm.2017.11.007

Fig. 3.

Fig. 3

Impact of J147 on pro-inflammatory markers and AMPK in diabetic mice. Western blot analysis of whole brain lysates showed a diabetes-induced increase in the protein levels of TNFα, TSPO, iNOS, and GFAP (A) and plasma C-reactive protein (B) that was reduced by J147 treatment. A significant decrease in phosphorylated AMPK in the brain of diabetic mice that was significantly attenuated by J147 (C). Data are group mean + SEM of n = 4/group. Statistical analysis by one-way ANOVA with Tukey-Kramer post hoc test. * = p < 0.05 vs Control + Vehicle, ** = p < 0.01 vs Control + Vehicle, + = p < 0.05 vs STZ + Vehicle.