Table 6.

Definitions for severity and time of occurrence of pericardial effusion

Clinically non-relevant	Requiring no intervention Treated pharmacologically
Clinically relevant	Treated with therapeutic pericardiocentesis Treated with surgical intervention Requiring blood transfusion Resulting in shock and/or death
LAAO therapy associated with epicardial approach	Clinically non-relevant (minor): Requiring no intervention, treated pharmacologically or <500 mL of bloody fluid was aspirated and not requiring blood transfusion or surgical intervention Clinically relevant (major): Aspiration of >500 mL of bloody fluid or an effusion that required blood transfusion or surgical intervention The presence or placement of pericardial catheter/drain at the end of the procedure should not be considered as clinically relevant effusion
Time of occurrence	Intraprocedural—occurred during the index procedure
	Acute—up to 48 h from the index procedure
	Late—more than 48 h from the index procedure