Table 1. Adult weight-based dosing guidelines for intensive phase and continuation phase TB treatment using fixed-dose combination (FDC) tablets by country.
These are the dosing guidelines used in the Predict TB study and are taken from the South African national TB guidelines 39 and the Chinese fixed drug combination tablet package insert from the Shenyang Hongqi Pharmaceutical Company, Ltd.
| Intensive Phase (initial 8 weeks) | Continuation Phase (weeks 9–24) | ||
|---|---|---|---|
| HRZE (75/150/400/275 mg) | HR (75/150 mg) | HR (150/300 mg) | |
| Weight | China and South Africa | South Africa | |
| 30–37 kg | 2 tablets daily | 2 tablets daily | -- |
| 38–54 kg | 3 tablets daily | 3 tablets daily | -- |
| 55–70 kg | 4 tablets daily | -- | 2 tablets daily |
| >70 kg | 5 tablets daily | -- | 2 tablets daily |
| China | |||
| <50 kg | -- | individual drug tablets
(non-FDC) |
|
| ≥50 kg | -- | 2 tablets daily | |
Note: H=isoniazid; R=rifampin; Z=pyrazinamide; E=ethambutol