Table 2. Predict TB early treatment completion criteria.

These are the criteria used at baseline, week 4, and week 16 to stratify enrolled participants to Arm A or Arm B vs C. Participants must meet all criteria to be eligible for randomization to Arm B vs C at week 16. Participants who do not meet all criteria are placed into Arm A.

Category	Criteria
Radiographic criteria	Baseline PET/CT:     •  No total lung collapse of a single side, AND     •  No pleural effusion, AND     •  No single cavity air volume on CT scan >30 mL, AND     •  CT scan hard volume (-100 to +100 HU density) <200 mL, AND     •  PET total activity <1500 units Week 4 PET/CT:     •  All individual cavities decrease by >20% (unless cavity <2 mL),        AND     •  CT scan hard volume does not increase by >10% unless the        increase is <5 mL, AND     •  PET total activity does not increase by >30% unless the        increase is <50 units
Bacterial load criterion	Week 16 Xpert cycle threshold ≥30
Adherence criterion	Minimum of 100 doses received by week 16