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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Surg Pathol Clin. 2017 Dec 8;11(1):123–145. doi: 10.1016/j.path.2017.09.009

Fig 16. Lobular carcinoma in situ involving collagenous spherulosis mimicking cribriform ductal carcinoma in situ.

Fig 16

Fig 16

a. H&E stain. b. Immunohistochemical stain for E-cadherin. Note the basement membrane-like material in the lumen and the dyshesive growth pattern of the neoplastic cells. The absent of immunoreactivity for E-cadherin in the neoplastic cells confirms the lobular phenotype. Magnification 200x.