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. 2018 Mar 7;15(3):e1002523. doi: 10.1371/journal.pmed.1002523

Table 1. Recommended elements for successful hypertension and human immunodeficiency virus (HIV) management integration.

Category Recommended elements Considerations for the HIV-infected population Used in Malawi hypertension-HIV program
Policy Population-level interventions (sodium reduction)
National clinical guidelines
Guidelines that consider drug interactions for hypertension treatment Developed algorithms for hypertension treatment that would minimize interactions with antiretrovirals
System strengthening Service delivery:
Standardized assessment
Simplified management protocols
Blood pressure measurement devices
CVD risk estimation
Task shifting
Training
Clinical mentorship
Supply chain:
Improved medication procurement and sustained availability
Access to fixed-dose combination medications
Community engagement:
Linkage to care
Community health workers
Leveraging existing infrastructure/systems
Benefit of angiotensin-converting enzyme inhibitors
Leverage HIV medication supply chain improvements
Enhanced adherence to complicated regimens to treat HIV and co-morbidities
Enhance PEPFAR service delivery
Service delivery:
Standardized assessment
Simplified management protocols
Blood pressure measurement devices
Task shifting
Training
Clinical mentorship
Supply chain:
Improved medication procurement and sustained availability
Leveraging existing infrastructure/systems
Innovation Promotion and use of available technology
Electronic health records
mHealth
Telemedicine
Point-of-care laboratory testing
Improve availability of fixed-dosed combination medications (e.g., medications with 2 active ingredients)
Electronic health records
Education Community:
Mass media campaigns
Population-level health promotion
Clinical:
Training of healthcare workers during formal education and in clinical practice
Culturally tailored educational materials
Leverage platforms for HIV education to include chronic disease education Clinical:
Training of healthcare workers during formal education and in clinical practice
Culturally tailored educational materials
Monitoring/evaluation Tracking/indicators
Registries/cohort monitoring
Clinical feedback loop (chart reviews, line listing, clinic-level control estimates, etc.)
Performance metrics for clinicians
Program evaluation using process and outcome indicators
Track HIV-specific indicators (e.g., ART adherence) Tracking/indicators
Registries/cohort monitoring
Clinical feedback loop (chart reviews, line listing, clinic-level control estimates, etc.)
Performance metrics for clinicians
Program evaluation using process and outcome indicators
Optimal hypertension care delivery Standardized screening and diagnosis using certified and calibrated devices
Education about disease prevention and counseling using culturally appropriate lifestyle modifications
Standardized treatment protocols
Task shifting
Cohort monitoring
Standardized screening and diagnosis using certified and calibrated devices
Education about disease prevention and counseling using culturally appropriate lifestyle modifications
Standardized treatment protocols
Task shifting
Cohort monitoring

Abbreviations: ART, antiretroviral therapy; CVD, cardiovascular disease; mHealth, mobile health; PEPFAR, President’s Emergency Plan for AIDS Relief. Cohort monitoring: use of longitudinal patient registers or electronic medical records systems to regularly monitor progress and outcomes.