Figure 5.

Distribution of CS over replication timing segments. A, Overlap between CS and RT classes. The absolute overlap between RT classes and CS, which are defined as genomic intervals sharing the same combinations of epigenetic marks. The chromatin classifications are based on Wang et al. (2015). The arrows under the graph indicate how RT overlap with each CS departs from the expected value based on total genome coverage (χ² adjusted residuals; Supplemental Table S4). Upward arrows are enriched, downward arrows are depleted, and the circles indicate no difference. B, Distribution of RT classes in CS. RT class coverage in each CS is expressed as a percentage of total coverage in that CS. The whole genome is reported as reference. C, Distribution of CS in RT classes. CS coverage in each RT class is expressed as a percentage of total coverage of that class. D, Correlation matrix between RT classes based on their distributions of CS. The correlation matrix shows the pairwise similarity between RT classes based on their relative CS coverage in C. Spearman correlation coefficients in each cell were used to draw a heat map (legend on the right).