Figure 7.

Chromatin long-range interactions and replication timing. A, Significant interactions identified by Hi-C analysis at 100-kb resolution (Liu et al., 2016) within chromosome 1 (P < 0.001). Replication timing segments are displayed in the outer circle, with the coordinates on the outside in Mb. The black lines connecting two 100-kb bins indicate their physical proximity in three-dimensional space. B, RT class composition of regions interacting with bins containing E, EM, M, ML, or L segments. Similar results were obtained when the bins in each interacting pair were switched (Supplemental Fig. S12). C, RT class composition of regions interacting with bins containing E, EM, M, ML, or L segments normalized for the total coverage of each group. The cumulative overlap of all the groups together is shown as reference. D, The correlation matrix shows the pairwise similarity of RT class coverage of bins interacting with bins containing E, EM, M, ML, or L segments (Supplemental Table S5). Spearman correlation coefficients in each cell were used to draw a heat map (legend on the right).