Table 1. Subtype classification according to BAGS for CLL sample cohorts.
| Cohort | n | BAGS Subtypes n (%) | ||||||
|---|---|---|---|---|---|---|---|---|
| Pre-BI | Pre-BII | Immature | Naive | Memory | Plasma cell | Unclassified | ||
| DUKE | 68 | 12 (17.6) | 1 (1.5) | 5 (7.4) | 13 (19.1) | 23 (33.8) | 3 (4.4) | 11 (16.2) |
| IDFCI | 124 | 15 (12.1) | 4 (3.2) | 13 (10.5) | 21 (16.9) | 49 (39.5) | 3 (2.4) | 19 (15.3) |
| IIDFCI | 83 | 11 (13.3) | 0 (0) | 6 (7.2) | 12 (14.5) | 38 (45.8) | 3 (3.6) | 13 (15.7) |
| MUNICH | 127 | 18 (14.2) | 5 (3.9) | 5 (3.9) | 30 (23.6) | 43 (33.9) | 7 (5.5) | 19 (15.0) |
| PADOVA | 112 | 14 (12.5) | 4 (3.6) | 7 (6.2) | 17 (15.2) | 51 (45.5) | 2 (1.8) | 17 (15.2) |
| ROCHE | 318 | 58 (18.2) | 10 (3.1) | 16 (5.0) | 93 (29.2) | 78 (24.5) | 15 (4.7) | 48 (15.1) |
| SAPIENZA | 62 | 8 (12.9) | 2 (3.2) | 0 (0.0) | 20 (32.3) | 20 (32.3) | 2 (3.2) | 10 (16.1) |
| UCSD | 130 | 13 (10.0) | 8 (6.2) | 8 (6.2) | 33 (25.4) | 42 (32.3) | 6 (4.6) | 20 (15.4) |
| Totala | 1024 | 149 (14.6) | 34 (3.3) | 60 (5.9) | 239 (23.3) | 344 (33.6) | 41 (4.0) | 157 (15.3) |
| Rangeb | 62–318 | 10.0–18.2 | 0.0–6.2 | 0.0–10.5 | 14.5–32.3 | 24.5–45.8 | 1.8–5.5 | 15.1–16.2 |
aThe total number and
bfrequency range for each subtype is listed. Tests for significantly different distributions across data sets were calculated using Fisher’s exact test (P = 0.02).