Table 3. Associations between BAGS subtypes and patient characteristics, based on available clinical data.
| Pre-BI | Pre-BII | Immature | Naïve | Memory | Plasma Cell | Total | |
|---|---|---|---|---|---|---|---|
| Age | |||||||
| < = 65 years | 21 (13.8) | 10 (6.6) | 8 (5.3) | 44 (28.9) | 64 (42.1) | 5 (3.3) | 152 |
| >65 years | 19 (18.4) | 1 (1.0) | 4 (3.9) | 23 (22.3) | 50 (48.5) | 6 (5.8) | 103 |
| Gender | |||||||
| Female | 21 (12.4) | 5 (3.0) | 18 (10.7) | 32 (18.9) | 83 (49.1) | 10 (5.9) | 169 |
| Male | 45 (17.2) | 10 (3.8) | 13 (5.0) | 68 (26.1) | 118 (45.2) | 7 (2.9) | 261 |
| Binet stage | |||||||
| A | 4 (8.7) | 1 (2.2) | 4 (8.7) | 14 (30.4) | 18 (39.1) | 5 (10.9) | 46 |
| B-C | 7 (25.0) | 1 (3.6) | 0 (0.0) | 12 (42.9) | 7 (25.0) | 1 (3.6) | 28 |
| Cytogenetic status | |||||||
| No marker | 7 (15.6) | 2 (4.4) | 2 (4.4) | 8 (17.8) | 22 (48.9) | 4 (8.9) | 45 |
| Del13q | 16 (16.2) | 3 (3.0) | 4 (4.0) | 26 (26.3) | 44 (44.4) | 6 (6.1) | 99 |
| Tri12 | 7 (25.0) | 0 (0.0) | 3 (10.7) | 3 (10.7) | 14 (50) | 1 (3.6) | 28 |
| Del11q | 4 (21.1) | 0 (0.0) | 2 (10.5) | 9 (47.4) | 4 (21.1) | 0 (0.0) | 19 |
| Del17p | 0 (0.0) | 0 (0.0) | 1 (8.3) | 1 (8.3) | 9 (75.0) | 1 (8.3) | 12 |
| ZAP-70 status | |||||||
| Positive | 24 (20.9) | 3 (2.6) | 14 (12.2) | 22 (19.1) | 48 (41.7) | 4 (3.5) | 115 |
| Negative | 20 (12.1) | 5 (3.0) | 15 (9.1) | 32 (19.4) | 89 (54.0) | 4 (2.4) | 165 |
| IgVH status | |||||||
| uIgVH | 35 (21.7) | 8 (5.0) | 20 (12.4) | 39 (24.2) | 53 (32.9) | 6 (3.7) | 161 |
| mIgVH | 31 (12.7) | 5 (2.0) | 15 (6.1) | 48 (19.7) | 135 (55.3) | 10 (4.1) | 244 |
Abbreviations: Del13q, deletion of 13q; Tri12, Trisomy; Del17p, deletion of 17p; Del11q, deletion of 11q; ZAP-70, zeta-chain-associated protein kinase 70; IgVH, immunoglobulin variable region heavy chain; mIgVH, mutated IgVH; uIgVH, unmutated IgVH.