Table 3. Expression of network nodes in IBD patients.
| NODE | EXPRESSION | NODE | EXPRESSION | NODE | EXPRESSION | NODE | EXPRESSION |
|---|---|---|---|---|---|---|---|
| PGN MDP LPS |
Altered | IL1b | Upregulated | Th2 | Upregulated | DC | Downregulated in Blood-Upregulated in mucosa |
| TLR2 | Upregulated | IFNg | Upregulated | IL4 | Altered | IEC_MICA_B | Upregulated |
| TLR4 | Upregulated | IL23 | Upregulated | IL15 | Upregulated | IEC_ULPB1_6 | Upregulated |
| NOD2 | Altered | IL22 | Upregulated | IL12 | Upregulated | CD8_NKG2D | Upregulated |
| NFkB | Altered | IL21 | Upregulated | IL13 | Upregulated | NK_NKG2D | Unknown |
| IL6 TNFa |
Upregulated Upregulated |
IL17 | Upregulated | Treg | Downregulated in Blood-Upregulated in mucosa | CD4_NKG2D | Upregulated |
| TGFb | Upregulated | IL10 | Upregulated | NK | Upregulated | FIBROBLAST | Upregulated |
| Th0 | Unknown | Th17 | Upregulated | DEF | Altered | MMPs | Upregulated |
| Th0_M | Upregulated | Th17_M | Upregulated | IL2 | Upregulated | PERFOR | Altered |
| IL18 | Upregulated | Th1 | Altered | MACR | Unknown | GRANZB | Upregulated |
A total of 31 nodes are reported as upregulated in IBD patients, 9 are reported to be altered (when different reports from literature are inconclusive or contradictory) and 3 nodes are unknown.