Table 5. Summary of renal morphology findings by light and electron microscopy.
| Mean number of glomeruli | 17 ± 6 (7–29) | |
| Light microscopy | ||
| Glomerular changes, n = 11 | Cases | Percentage |
| Mean % globally sclerosed glomeruli | 43 ± 20 (8–75) % | |
| % globally sclerosed glomeruli | ||
| <25% | 2 | 18% |
| 25–50% | 4 | 36% |
| >50% | 5 | 45% |
| Segmental scleroses | 0 | 0% |
| Glomerular hypertrophy | ||
| 0 | 0 | 0% |
| 1 | 6 | 55% |
| 2 | 4 | 36% |
| 3 | 1 | 9% |
| Wrinkled GBM / Periglomerular fibrosis | ||
| Yes | 7 | 64% |
| No | 4 | 36% |
| Tubulointerstitial changes, n = 11 | ||
| Tubular atrophy | ||
| 0 | 0 | 0% |
| 1 | 10 | 91% |
| 2 | 1 | 9% |
| 3 | 0 | 0% |
| Interstitial fibrosis | ||
| 0 | 0 | 0% |
| 1F | 6 | 55% |
| 2F | 4 | 36% |
| 3F | 1 | 9% |
| Interstitial inflammation | ||
| 0 | 2 | 18% |
| 1 | 5 | 45% |
| 2 | 2 | 18% |
| 3 | 2 | 18% |
| Vascular changes, n = 10 | ||
| Intimal thickening, n = 10 | ||
| 0 | 5 | 50% |
| 1 | 2 | 20% |
| 2 | 3 | 30% |
| 3 | 0 | 0% |
| Smooth muscle hyperplasia, n = 10 | ||
| 0 | 6 | 60% |
| 1 | 4 | 40% |
| 2 | 0 | 0% |
| 3 | 0 | 0% |
| Arteriolar hyalinosis, n = 11 | ||
| 0 | 1 | 9% |
| 1 | 7 | 64% |
| 2 | 3 | 27% |
| 3 | 0 | 0% |
| Electron microscopy, n = 11 | ||
| GBM thickness (nm) | 307 ± 39 (259–349) | |
| Podocyte foot processes (slits/μm GBM) | 1.5 ± 0.2 (1.2–1.8) | |
| Podocyte foot process effacement | ||
| No (normal) | 11 | 100% |
| Segmental effacement | 2 | 18% |
| Widespread effacement | 0 | 0% |
| Endothelial cells | ||
| Normal | 11 | 100% |
| Swollen | 0 | 0% |
| Podocyte cytoplasm inclusions | ||
| Yes | 9 | 82% |
| No | 2 | 18% |
| Immune complex deposits | ||
| Yes | 0 | 0% |
| No | 11 | 100% |
Results are presented as mean ± SD (range) or cases and percentage.
Abbreviations: GBM, glomerular basement membrane.