Table 4. The enriched top 15 GO terms of miRNA signature targets.
| GO Items | Items Details | No. of genes | FDR |
|---|---|---|---|
| Biological process | |||
| GO:0035556 | intracellular signal transduction | 4 | 0.0001536 |
| GO:0008283 | cell proliferation | 3 | 0.0001913 |
| GO:0007596 | blood coagulation | 3 | 0.0001913 |
| GO:0030168 | platelet activation | 3 | 0.0001913 |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 3 | 0.0001913 |
| GO:0045087 | innate immune response | 3 | 0.0001913 |
| GO:0007165 | signal transduction | 3 | 0.0002376 |
| GO:0051146 | nerve growth factor receptor signaling pathway | 3 | 0.0002376 |
| GO:0048011 | striated muscle cell differentiation | 3 | 0.0002376 |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 18 | 0.0002497 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 6 | 0.0003527 |
| GO:0018105 | peptidyl-serine phosphorylation | 3 | 0.000354 |
| GO:0043066 | negative regulation of apoptotic process | 3 | 0.000354 |
| GO:0007281 | germ cell development | 3 | 0.000354 |
| GO:0006464 | protein modification process | 3 | 0.0007776 |
| Molecular function | |||
| GO:0005515 | protein binding | 89 | 7.47E-12 |
| GO:0000166 | nucleotide binding | 51 | 5.97E-09 |
| GO:0046872 | metal ion binding | 59 | 5.34E-08 |
| GO:0005524 | ATP binding | 33 | 5.95E-05 |
| GO:0046872 | metal ion binding | 37 | 6.92E-05 |
| GO:0008270 | zinc ion binding | 38 | 0.0001139 |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | 7 | 0.0001349 |
| GO:0003677 | DNA binding | 7 | 0.0001768 |
| GO:0031625 | ubiquitin protein ligase binding | 4 | 0.0002863 |
| GO:0008134 | transcription factor binding | 11 | 0.0003429 |
| GO:0005525 | GTP binding | 4 | 0.0004299 |
| GO:0019003 | GDP binding | 4 | 0.0004299 |
| GO:0003924 | GTPase activity | 4 | 0.0004299 |
| GO:0003690 | double-stranded DNA binding | 6 | 0.0005831 |
| GO:0003697 | single-stranded DNA binding | 3 | 0.0009546 |
| Cellular component | |||
| GO:0005634 | nucleus | 112 | 5.68E-17 |
| GO:0005737 | cytoplasm | 106 | 3.66E-15 |
| GO:0016020 | membrane | 76 | 7.10E-09 |
| GO:0005829 | cytosol | 39 | 1.04E-07 |
| GO:0005730 | nucleolus | 38 | 1.10E-07 |
| GO:0043231 | intracellular membrane-bounded organelle | 11 | 1.23E-07 |
| GO:0016021 | integral to membrane | 53 | 8.89E-06 |
| GO:0043231 | intracellular membrane-bounded organelle | 13 | 1.73E-05 |
| GO:0016021 | integral to membrane | 68 | 4.08E-05 |
| GO:0005622 | intracellular | 26 | 0.0001472 |
| GO:0005654 | nucleoplasm | 14 | 0.0001523 |
| GO:0005625 | soluble fraction | 4 | 0.0001675 |
| GO:0005886 | plasma membrane | 4 | 0.0001675 |
| GO:0005624 | membrane fraction | 16 | 0.0002292 |
| GO:0005625 | soluble fraction | 8 | 0.000391 |
No.: number; FDR: false discovery rate.