Table 1. Mean serum bile acid concentrations in healthy subjects by age and gender.
| Gender | BAa | Age <40 | Age 40–60 | Age >60 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n = 30 | n = 59 | n = 28 | ||||||||
| Mean±SEM | 10th | 90th | Mean±SEM | 10th | 90th | Mean±SEM | 10th | 90th | ||
| MALE | CA | 48.1 ± 9.9 | 12.4 | 108.8 | 46.0 ±9.5 | 6.3 | 82.0 | 91.0 ± 38.9 | 6.6 | 202.6 |
| GCA | 192.5 ± 34.7 | 34.0 | 509.9 | 181.3 ± 45.7 | 32.8 | 303.2 | 168.1 ± 39.5 | 14.4 | 423.7 | |
| TCA | 22.3 ± 4.6 | 4.1 | 62.2 | 28.2 ± 7.4 | 3.3 | 48.7 | 29.0 ± 7.5 | 3.4 | 90.8 | |
| CDCA | 196.6 ± 50.9 | 15.0 | 469.8 | 126.7 ± 26.2 | 14.1 | 286.6 | 141.8 ± 53.0 | 9.5 | 423.9 | |
| GCDCA | 631.2 ± 118.6 | 111.2 | 1542.0 | 492.6 ± 103.6 | 95.3 | 758.6 | 431.1 ± 80.3 | 65.6 | 1083.0 | |
| TCDCA | 69.2 ± 11.9 | 13.5 | 144.6 | 81.6 ± 20.9 | 11.0 | 146.6 | 58.2 ± 12.5 | 12.1 | 127.6 | |
| DCA | 196.8 ± 29.6 | 44.2 | 316.2 | 174.9 ± 16.6 | 30.3 | 343.0 | 199.1 ± 39.2 | 38.8 | 395.6 | |
| GDCA | 286.7 ± 69.2 | 18.3 | 701.2 | 211.0 ± 49.0 | 24.6 | 364.2 | 260.1 ± 73.5 | 23.2 | 848.6 | |
| TDCA | 33.1 ± 7.4 | 1.6 | 88.6 | 32.3 ± 7.0 | 3.4 | 61.4 | 37.4 ± 11.1 | 3.9 | 99.1 | |
| TBA | 4.2 ± 0.6 | 1.5 | 8.5 | 4.4 ± 0.9 | 1.6 | 6.3 | 4.0 ± 0.9 | 1.1 | 11.8 | |
| Age <40 | Age 40–60 | Age >60 | ||||||||
| n = 59 | n = 98 | n = 40 | ||||||||
| Mean±SEM | 10th | 90th | Mean±SEM | 10th | 90th | Mean±SEM | 10th | 90th | ||
| FEMALE | CA | 41.3 ± 7.7 | 6.6 | 91.5 | 65.2 ± 15.7 | 4.2 | 164.5 | 103.8 ± 47.3 | 5.8 | 160.3 |
| GCA | 346.3 ± 172.1 | 31.2 | 595.4 | 209.3 ± 41.7 | 27.7 | 418.3 | 176.8 ± 30.5 | 24.2 | 332.9 | |
| TCA | 78.6 ± 51.3 | 5.2 | 77.8 | 42.2 ± 11.2 | 3.6 | 75.4 | 53.4 ± 23.9 | 3.5 | 67.4 | |
| CDCA | 121.6 ± 23.6 | 14.2 | 275.2 | 122.4 ± 24.4 | 12.9 | 299.8 | 163.0 ± 51.9 | 13.5 | 300.8 | |
| GCDCA | 860.6 ± 303.3 | 96.3 | 1326.0 | 535.0 ± 55.6 | 94.7 | 1229.0 | 500.4 ± 70.5 | 86.2 | 1203.0 | |
| TCDCA | 127.7 ± 44.8 | 14.4 | 241.8 | 80.9 ± 11.4 | 13.2 | 161.1 | 102.0 ± 27.3 | 13.6 | 202.2 | |
| DCA | 207.5 ± 23.3 | 42.2 | 442.5 | 203.3 ± 18.3 | 40.1 | 496.8 | 278.3 ± 50.7 | 64.9 | 543.1 | |
| GDCA | 436.6 ± 134.7 | 38.1 | 775.0 | 315.3 ± 50.0 | 34.6 | 612.4 | 264.2 ± 44.5 | 55.5 | 653.2 | |
| TDCA | 68.4 ± 22.8 | 6.6 | 94.1 | 44.5 ± 7.6 | 4.5 | 96.2 | 59.2 ± 19.4 | 7.3 | 106.6 | |
| TBA | 6.2 ± 1.8 | 1.2 | 8.6 | 4.7 ± 0.5 | 1.4 | 8.7 | 4.7 ± 0.6 | 1.5 | 9.5 | |
BA, bile acids; TBA, total bile acids; SEM, standard error of the mean; CA, cholic acid; GCA, glycocholic acid; TCA, taurocholic acid; CDCA, chenodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; TCDCA, taurochenodeoxycholic acid; DCA, deoxycholic acid; TDCA, taurodeoxycholic acid; IBAs, Individual Bile Acids.
a The units for TBA are umol/L; the units for all other BA are ng/mL.