Fig 8. Results of the simulations in pathological conditions with an injection of 1 μM morphine have been denoted.

Synaptic glutamate is shown in (A), gliotransmitter dynamics is denoted in (B), presynaptic IP3 variation and Ca²⁺ oscillations are shown in (C) and (D), respectively, postsynaptic Ca²⁺ is shown in (E), and finally, phosphorylated CaMKII and the threshold for NOs are shown in (F) with red and green lines, respectively.