Fig 17. Effect of Nic, ETOH, and mecamylamine (Mec) on temporal changes in [Ca²⁺]_i in individual HBO cells.

(A) Shows a representative HBO cell that responded with a dose-dependent increase in FIR when stimulated with 0.01, 0.05 and 1.0 mM Nic. (B) Shows 1 out of 8 HBO cells that responded with a transient increase in FIR when stimulated with 50 mM ETOH. Two additional cells responded with a small but significant increase in FIR when stimulated with 50 mM ETOH. (C) Shows another representative HBO cell that responded with an increase in FIR in the presence of 1 mM Nic. Mec (50 μM) inhibited the Nic-induced increase in FIR. In each cell, the FIR was normalized to 1 with respect to its value under the control conditions.