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. 2017 Oct 5;2(19):e95890. doi: 10.1172/jci.insight.95890

Figure 2. Induction of hypercholesterolemia and atherosclerosis in mosaic mice.

Figure 2

(A) Plasma total cholesterol measured at 12, 24, and 36 weeks after rAAV8-D377Y-PCSK9 injection. (B) Atherosclerosis measured at the level of the commissures of the aortic valves revealing a retarding effect of the Confetti transgene on atherogenesis. P = 0.004 for difference between genotypes (2-way ANOVA). n = 8–10 and n = 15–20 at each time point for WT and Confetti mice, respectively. (C) Recombination rate determined among nucleated medial SMC profiles at 3 levels of the aortic root in 12 Confetti mice starting at the commissures of the aortic valves. (D) Dot plot showing the average percentage-wise distribution of fluorescence colors in the mosaic mice. An example of an analyzed arterial media is shown on the left.